Small customizations are possible with code injections. Bigger changes would make sense using a custom theme. These are Ghost themes, so if you have one or can buy one we might publish it on nostr and make it available. Don't rush buying though, because it might not be fully functional (we only support a subset of Ghost features), and tools for publishing aren't good yet (I'd have to publish it myself probably), and the theme would be publicly available to anyone.
No new themes in the pipeline atm, I published all good generic open-source Ghost themes, if you find a promising one - let me know.